Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia.

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作者： Hubert,Hackl ^[1] ; Ksenia,Astanina ^[2] ; Rotraud,Wieser ^[3]

作者单位： Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innrain 80, 6020, Innsbruck, Austria. ^[1] Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Austria. ^[2] Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Austria. rotraud.wieser@meduniwien.ac.at. ^[3]

关键词 Acute myeloid leukemia Clonal evolution Copy number variation Cytogenetics DNA methylation Gene expression profiling Relapse Single nucleotide variants Therapy resistance

主题词克隆细胞(Clone Cells);疾病恶化(Disease Progression);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);复发(Recurrence)

DOI 10.1186/s13045-017-0416-0

PMID 28219393

发布时间 2024-12-11

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