Membrane cholesterol access into a G-protein-coupled receptor.

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作者： Ramon,Guixà-González ^[1] ; José L,Albasanz ^[2] ; Ismael,Rodriguez-Espigares ^[3] ; Manuel,Pastor ^[1] ; Ferran,Sanz ^[1] ; Maria,Martí-Solano ^[1] ; Moutusi,Manna ^[1] ; Hector,Martinez-Seara ^[4] ; Peter W,Hildebrand ^[4] ; Mairena,Martín ^[5] ; Jana,Selent ^[2]

作者单位： Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. ^[1] Institut für Medizinische Physik und Biophysik, AG ProteiInformatics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. ^[2] Department of Inorganic Chemistry, Organic Chemistry, and Biochemistry, Faculty of Science and Chemical Technologies and Faculty of Medicine of Ciudad Real. Regional Center of Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), 13071 Ciudad Real, Spain. ^[3] Department of Physics, Tampere University of Technology (TUT), PO Box 692, FI-33101 Tampere, Finland. ^[4] Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, CZ-16610 Prague, Czech Republic. ^[5]

主题词动物(Animals);结合部位(Binding Sites);结合, 竞争性(Binding, Competitive);细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);胆固醇(Cholesterol);分子动力学模拟(Molecular Dynamics Simulation);蛋白质结合(Protein Binding);大鼠(Rats);受体, 腺苷A2A(Receptor, Adenosine A2A);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1038/ncomms14505

PMID 28220900

发布时间 2018-11-26

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Nature communications

2017年8卷

14505页

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Membrane cholesterol access into a G-protein-coupled receptor.

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Membrane cholesterol access into a G-protein-coupled receptor.

Nature communications

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