Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites.

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作者： Yi-Qian,Sun ^[1] ; Tobias,Busche ^[2] ; Christian,Rückert ^[3] ; Constanze,Paulus ^[3] ; Yuriy,Rebets ^[4] ; Renata,Novakova ^[5] ; Jörn,Kalinowski ^[4] ; Andriy,Luzhetskyy ^[6] ; Jan,Kormanec ^[3] ; Olga N,Sekurova ^[4] ; Sergey B,Zotchev ^[5]

作者单位： Department of Biotechnology, Norwegian University of Science and Technology , 7491 Trondheim, Norway. ^[1] The Department of Laboratory Medicine, Children's and Women's Health (LBK), Norwegian University of Science and Technology , 7491 Trondheim, Norway. ^[2] Center for Biotechnology, Bielefeld University , Universitätsstraße 27, 33615 Bielefeld, Germany. ^[3] Helmholtz Institute for Pharmaceutical Research Saarland , Actinobacteria Metabolic Engineering Group, 66123 Saarbrücken, Germany. ^[4] Universität des Saarlandes , Pharmaceutical Biotechnology, 66123 Saarbrücken, Germany. ^[5] Institute of Molecular Biology, Slovak Academy of Sciences , 845 51 Bratislava, Slovak Republic. ^[6] Department of Pharmacognosy, University of Vienna , 1090 Vienna, Austria. ^[7]

关键词 Streptomyces TetR repressor biosensor orphan gene clusters secondary metabolite biosynthesis

主题词细菌蛋白质类(Bacterial Proteins);生物传感技术(Biosensing Techniques);药物发现(Drug Discovery);代谢组(Metabolome);多基因族(Multigene Family);灵菌红素(Prodigiosin);链霉菌属(Streptomyces)

DOI 10.1021/acssynbio.6b00353

PMID 28221784

发布时间 2018-03-12

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