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In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

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第一作者： Thomas,Colley

第一单位： Pulmocide Ltd., London, United Kingdom.

作者： Thomas,Colley ^[1] ; Alexandre,Alanio ^[2] ; Steven L,Kelly ^[3] ; Gurpreet,Sehra ^[1] ; Yasuo,Kizawa ^[4] ; Andrew G S,Warrilow ^[3] ; Josie E,Parker ^[3] ; Diane E,Kelly ^[3] ; Genki,Kimura ^[4] ; Lauren,Anderson-Dring ^[1] ; Takahiro,Nakaoki ^[4] ; Mihiro,Sunose ^[5] ; Stuart,Onions ^[5] ; Damien,Crepin ^[5] ; Franz,Lagasse ^[5] ; Matthew,Crittall ^[5] ; Jonathan,Shannon ^[5] ; Michael,Cooke ^[5] ; Stéphane,Bretagne ^[2] ; John,King-Underwood ^[6] ; John,Murray ^[1] ; Kazuhiro,Ito ^[7] ; Pete,Strong ^[1] ; Garth,Rapeport ^[1]

作者单位： Pulmocide Ltd., London, United Kingdom. ^[1] Institut Pasteur, CNRS, Molecular Mycology Unit, French National Reference Center for Invasive Mycoses & Antifungals, URA3012, Paris, France.;Paris Diderot, Sorbonne Paris Cité University, Paris, France.;Parasitology-Mycology Laboratory, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France. ^[2] Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Wales, United Kingdom. ^[3] Nihon University, Chiba, Japan. ^[4] Sygnature Discovery Ltd., Nottingham, United Kingdom. ^[5] Compchem Resource, Pendock, United Kingdom. ^[6] Pulmocide Ltd., London, United Kingdom kaz@pulmocide.com. ^[7]

关键词 Aspergillus fumigatus CYP51 azole azole resistant inhalation long acting