Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.
第一作者:
Ayumi,Kurita
第一单位:
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (A.K., Y.M., H.Y., Y.I.), Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (S.I.), and Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA, Australia (P.I.M.).
作者:
主题词
动物(Animals);杆状病毒科(Baculoviridae);基因表达谱(Gene Expression Profiling);葡糖醛酸基转移酶(Glucuronosyltransferase);同工酶类(Isoenzymes);肝(Liver);代谢解毒, Ⅱ期(Metabolic Detoxication, Phase II);小鼠(Mice);吗啡(Morphine);底物特异性(Substrate Specificity)
DOI
10.1124/jpet.117.240382
PMID
28228532
发布时间
2018-11-19
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