Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in <i>Caenorhabditis elegans</i>.
第一作者:
Natallia,Kalinava
第一单位:
Department of Molecular Biology and Biochemistry, Rutgers the State University of New Jersey, Piscataway, NJ 08854 USA.
作者:
医学主题词
动物(Animals);秀丽新小杆线虫(Caenorhabditis elegans);漂亮新小杆线虫蛋白质类(Caenorhabditis elegans Proteins);载体蛋白质类(Carrier Proteins);染色质免疫沉淀法(Chromatin Immunoprecipitation);基因组(Genome);基因组不稳定性(Genomic Instability);生殖细胞(Germ Cells);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);组蛋白类(Histones);甲基化(Methylation);显微镜检查, 荧光(Microscopy, Fluorescence);诱变(Mutagenesis);RNA干扰(RNA Interference);RNA, 双链(RNA, Double-Stranded);RNA, 信使(RNA, Messenger);RNA, 小分子干扰(RNA, Small Interfering);序列分析, RNA(Sequence Analysis, RNA);转录, 遗传(Transcription, Genetic)
DOI
10.1186/s13072-017-0114-8
PMID
28228846
发布时间
2018-12-02
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