Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.

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作者： Mian,Cao ^[1] ; Yumei,Wu ^[1] ; Ghazaleh,Ashrafi ^[2] ; Amber J,McCartney ^[1] ; Heather,Wheeler ^[1] ; Eric A,Bushong ^[3] ; Daniela,Boassa ^[3] ; Mark H,Ellisman ^[4] ; Timothy A,Ryan ^[2] ; Pietro,De Camilli ^[5]

作者单位： Departments of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, Kavli Institute for Neuroscience, School of Medicine, Yale University, New Haven, CT 06510, USA. ^[1] Department of Biochemistry, Weill Cornell Medical College, New York, NY 10021, USA. ^[2] Center for Research in Biological Systems and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] Center for Research in Biological Systems and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ^[4] Departments of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, Kavli Institute for Neuroscience, School of Medicine, Yale University, New Haven, CT 06510, USA. Electronic address: pietro.decamilli@yale.edu. ^[5]

关键词 LRRK2 PARK19 PARK2 PARK20 PI(4,5)P2 Parkin auxilin neurodegeneration nigrostriatal pathway synaptic vesicle endocytosis synaptojanin 1