Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.

导出 OA

翻译打印收藏纠错

作者： Daniela,Weber ^[1] ; Robert R,Jenq ^[2] ; Jonathan U,Peled ^[3] ; Ying,Taur ^[4] ; Andreas,Hiergeist ^[5] ; Josef,Koestler ^[5] ; Katja,Dettmer ^[6] ; Markus,Weber ^[7] ; Daniel,Wolff ^[8] ; Joachim,Hahn ^[8] ; Eric G,Pamer ^[4] ; Wolfgang,Herr ^[8] ; André,Gessner ^[5] ; Peter J,Oefner ^[6] ; Marcel R M,van den Brink ^[9] ; Ernst,Holler ^[8]

作者单位： Department of Hematology and Oncology, Internal Medicine III, University Medical Center, Regensburg, Germany. Electronic address: daniela.weber@ukr.de. ^[1] Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[2] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. ^[3] Department of Medicine, Weill Cornell Medical College, New York, New York; Infectious Diseases Services, Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, New York. ^[4] Institute of Clinical Microbiology and Hygiene, University Medical Center, Regensburg, Germany. ^[5] Institute of Functional Genomics, University of Regensburg, Regensburg, Germany. ^[6] Department of Orthopedic Surgery, University Medical Center, Regensburg, Germany. ^[7] Department of Hematology and Oncology, Internal Medicine III, University Medical Center, Regensburg, Germany. ^[8] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[9]

关键词 Acute intestinal GVHD Allogeneic stem cell transplantation Intestinal microbiome Outcome Treatment with broad-spectrum antibiotics