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Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative.

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第一作者: Tine,Cuppens
第一单位: Department of Oncology, Gynecologic Oncology, KU Leuven (University of Leuven), Leuven, Belgium.
作者单位: Department of Oncology, Gynecologic Oncology, KU Leuven (University of Leuven), Leuven, Belgium. [1] Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven (University of Leuven), Leuven, Belgium.;Department of Gynaecology and Obstetrics, Leuven Cancer Institute, UZ Leuven, Leuven, Belgium. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.;Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway. [3] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. [4] Biomedical Research Group in Gynecology, Vall d'Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.;Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Arnau de Vilanova University Hospital, University of Lleida, IRB Lleida, Lleida, Spain. [5] Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain. [6] Department of Pathology, GROW - School for Oncology & Developmental Biology, Maastricht University Medical Centre, the Netherlands. [7] Department of Gynecology and Obstetrics, GROW - School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands. [8] Laboratory for Pathology Oost Nederland, Hengelo, The Netherlands. [9] Department of Obstetrics and Gynecology, Gynecological Oncology Center, Charles University in Prague - 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic. [10] Department of Pathology, Charles University in Prague - 1st Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic. [11] Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland. [12] Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.;Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. [13] Institute of Pathology, Medical University of Graz, Graz, Austria. [14] Department of Pathology, Hospital of the Sisters of Charity, Linz, Austria. [15] Department of Gynecologic Oncology, Oncology Center, Provincial Hospitals Gdynia, Gdynia, Poland. [16] Institut de Pathologie et de Génétique, Brussels, Belgium. [17] Department of Gynecological Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands. [18] Department of Obstetrics and Gynecology, Radboud University Medical Centre Nijmegen, Nijmegen, the Netherlands. [19] Department of Obstetrics and Gynecology, University of Bonn, Bonn, Germany. [20] Institute of Pathology, University Hospital Cologne, Cologne, Germany. [21] Department of Women's and Children's Health, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden. [22] Department of Development and Regeneration, KU Leuven (University of Leuven), Leuven, Belgium. [23] Department of Oncology, Trace Platform, KU Leuven (University of Leuven) - UZ Leuven, Leuven, Belgium. [24] Department of Pathology, UZ Leuven - KU Leuven (University of Leuven), Leuven, Belgium. [25] Department of Oncology, Gynecologic Oncology, KU Leuven (University of Leuven), Leuven, Belgium. frederic.amant@uzleuven.be.;Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek - Netherlands Cancer Institute, Amsterdam, the Netherlands. [26]
DOI 10.1158/1078-0432.CCR-16-2149
PMID 28232476
发布时间 2021-12-04
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Clinical cancer research : an official journal of the American Association for Cancer Research

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