APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis.

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作者： Carole H,Sudre ^[1] ; M Jorge,Cardoso ^[2] ; Chris,Frost ^[3] ; Josephine,Barnes ^[4] ; Frederik,Barkhof ^[5] ; Nick,Fox ^[4] ; Sébastien,Ourselin ^[2] ; Alzheimer's Disease Neuroimaging Initiative

作者单位： Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London, UK; Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK. Electronic address: carole.sudre.12@ucl.ac.uk. ^[1] Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London, UK; Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK. ^[2] Department of Medical Statistics, London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and Medical Health, University College London, London, UK. ^[3] Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK. ^[4] Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London, UK; Department of Radiology & Nuclear Medicine, VU University Medical Centre, Amsterdam, the Netherlands. ^[5]

关键词 APOE Alzheimer's disease Longitudinal White matter hyperintensities