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NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.

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第一作者： Elisabeth,Krones

第一单位： Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.

作者： Elisabeth,Krones ^[1] ; Kathrin,Eller ^[2] ; Marion J,Pollheimer ^[3] ; Silvia,Racedo ^[1] ; Alexander H,Kirsch ^[2] ; Bianca,Frauscher ^[2] ; Annika,Wahlström ^[4] ; Marcus,Ståhlman ^[4] ; Michael,Trauner ^[5] ; Florian,Grahammer ^[6] ; Tobias B,Huber ^[7] ; Karin,Wagner ^[8] ; Alexander R,Rosenkranz ^[2] ; Hanns-Ulrich,Marschall ^[4] ; Peter,Fickert ^[9]

作者单位： Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. ^[1] Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Austria. ^[2] Department of Pathology, Medical University of Graz, Austria. ^[3] Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden. ^[4] Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. ^[5] Department of Medicine IV, Medical Center and Faculty of Medicine, University of Freiburg, Germany. ^[6] Department of Medicine IV, Medical Center and Faculty of Medicine, University of Freiburg, Germany; BIOSS Center for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany; FRIAS - Freiburg Institute for Advanced Studies and ZBSA - Center for Systems Biology, Albert-Ludwigs-University, Freiburg, Germany. ^[7] Core Facility Molecular Biology, Center for Medical Research, Medical University Graz, Graz, Austria. ^[8] Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address: peter.fickert@medunigraz.at. ^[9]

关键词 Acute kidney injury Bile acid therapy Bile acids Bile cast nephropathy Kidney fibrosis Liver cirrhosis Renal failure