首页> Acta neuropathologica> Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

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第一作者： Yuetiva,Deming

第一单位： Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.

作者： Yuetiva,Deming ^[1] ; Zeran,Li ^[1] ; Manav,Kapoor ^[2] ; Oscar,Harari ^[1] ; Jorge L,Del-Aguila ^[1] ; Kathleen,Black ^[1] ; David,Carrell ^[1] ; Yefei,Cai ^[1] ; Maria Victoria,Fernandez ^[1] ; John,Budde ^[1] ; Shengmei,Ma ^[1] ; Benjamin,Saef ^[1] ; Bill,Howells ^[1] ; Kuan-Lin,Huang ^[3] ; Sarah,Bertelsen ^[2] ; Anne M,Fagan ^[4] ; David M,Holtzman ^[5] ; John C,Morris ^[5] ; Sungeun,Kim ^[6] ; Andrew J,Saykin ^[7] ; Philip L,De Jager ^[8] ; Marilyn,Albert ^[9] ; Abhay,Moghekar ^[9] ; Richard,O'Brien ^[10] ; Matthias,Riemenschneider ^[11] ; Ronald C,Petersen ^[12] ; Kaj,Blennow ^[13] ; Henrik,Zetterberg ^[14] ; Lennart,Minthon ^[15] ; Vivianna M,Van Deerlin ^[16] ; Virginia Man-Yee,Lee ^[16] ; Leslie M,Shaw ^[16] ; John Q,Trojanowski ^[16] ; Gerard,Schellenberg ^[16] ; Jonathan L,Haines ^[17] ; Richard,Mayeux ^[18] ; Margaret A,Pericak-Vance ^[19] ; Lindsay A,Farrer ^[20] ; Elaine R,Peskind ^[21] ; Ge,Li ^[22] ; Antonio F,Di Narzo ^[23] ; Alzheimer’s Disease Neuroimaging Initiative (ADNI) ^[24] ; Alzheimer Disease Genetic Consortium (ADGC) ^[2] ; John S K,Kauwe ^[25] ; Alison M,Goate ; Carlos,Cruchaga

作者单位： Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. ^[1] Department of Neuroscience, Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[2] Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.;McDonnell Genome Institute, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. ^[3] Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.;Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.;Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA. ^[4] Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.;Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.;Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.;Department of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA. ^[5] Indiana Alzheimer Disease Center and Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Electrical and Computer Engineering, State University of New York, Oswego, NY, 13126, USA. ^[6] Indiana Alzheimer Disease Center and Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA. ^[7] Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Institute for the Neurosciences, Brigham and Women's Hospital, Boston, MA, 02115, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Program in Medical and Population Genetics, Broad Institute of Harvard University and M.I.T., Cambridge, MA, 02142, USA. ^[8] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[9] Department of Neurology, Duke Medical Center, Box 2900, Durham, NC, 27710, USA. ^[10] Clinic of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany. ^[11] Department of Neurology, Mayo Clinic, Rochester, MN, USA. ^[12] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden. ^[13] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden.;Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK. ^[14] Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden. ^[15] Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. ^[16] Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA. ^[17] Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. ^[18] The John P. Hussman Institute for Human Genomics, and Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA. ^[19] Departments of Biostatistics, Medicine (Genetics Program), Ophthalmology, Epidemiology, and Neurology, Boston University, Boston, MA, USA. ^[20] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.;VISN-20 Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA. ^[21] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.;VISN-20 Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA. ^[22] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[23] Department of Biology, Brigham Young University, Provo, UT, USA. ^[24] Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. ccruchaga@wustl.edu.;Department of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA. ccruchaga@wustl.edu. ^[25]

关键词 Alzheimer’s disease Cerebrospinal fluid biomarkers Endophenotype Genome-wide association study