Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

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作者： Tim,Cernak ^[1] ; Nathan J,Gesmundo ^[1] ; Kevin,Dykstra ^[1] ; Yang,Yu ^[1] ; Zhicai,Wu ^[1] ; Zhi-Cai,Shi ^[1] ; Petr,Vachal ^[1] ; Donald,Sperbeck ^[1] ; Shuwen,He ^[1] ; Beth Ann,Murphy ^[1] ; Lisa,Sonatore ^[1] ; Steven,Williams ^[1] ; Maria,Madeira ^[1] ; Andreas,Verras ^[1] ; Maud,Reiter ^[1] ; Claire Heechoon,Lee ^[1] ; James,Cuff ^[1] ; Edward C,Sherer ^[1] ; Jeffrey,Kuethe ^[1] ; Stephen,Goble ^[1] ; Nicholas,Perrotto ^[1] ; Shirly,Pinto ^[1] ; Dong-Ming,Shen ^[1] ; Ravi,Nargund ^[1] ; James,Balkovec ^[1] ; Robert J,DeVita ^[1] ; Spencer D,Dreher ^[1]

作者单位： Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States. ^[1]

主题词色谱法, 液相(Chromatography, Liquid);二酰甘油O-酰基转移酶(Diacylglycerol O-Acyltransferase);酶抑制剂(Enzyme Inhibitors);质谱分析法(Mass Spectrometry)

DOI 10.1021/acs.jmedchem.6b01543

PMID 28252959

发布时间 2018-12-22

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