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首页> Aging cell> Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction.

Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction.

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作者： Namiki,Fujii ^[1] ; Takumi,Narita ^[1] ; Naoyuki,Okita ^[2] ; Masaki,Kobayashi ^[2] ; Yurika,Furuta ^[3] ; Yoshikazu,Chujo ^[1] ; Masahiro,Sakai ^[2] ; Atsushi,Yamada ^[1] ; Kanae,Takeda ^[1] ; Tomokazu,Konishi ^[1] ; Yuka,Sudo ^[1] ; Isao,Shimokawa ^[1] ; Yoshikazu,Higami ^[4]

作者单位： Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. ^[1] Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. ^[2] Department of Internal Medicine Research, Sasaki Institute, Sasaki Foundation, 2-2 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. ^[3] Faculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjo, Nakano, Akita, 010-0195, Japan. ^[4] Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. ^[5]

关键词 caloric restriction (CR)mitochondria biogenesis oxidative stress peroxisome proliferator-activated receptor gamma coactivator-1α (Pgc-1α)sterol regulatory element binding protein-1c (Srebp-1c)white adipose tissue (WAT)

主题词脂肪组织, 白色(Adipose Tissue, White);衰老(Aging);动物(Animals);热量限制(Caloric Restriction);胚胎, 哺乳动物(Embryo, Mammalian);脂肪酸类(Fatty Acids);女(雌)性(Female);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);谷胱甘肽(Glutathione);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);线粒体(Mitochondria);信号传导(Signal Transduction);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1)

DOI 10.1111/acel.12576

PMID 28256090

发布时间 2018-11-13

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Aging cell

Aging cell

2017年16卷3期

508-517页

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