第一单位：
CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal.
作者：
Rita Machado,de Oliveira [1]
;
Hugo,Vicente Miranda [1]
;
Laetitia,Francelle [2]
;
Raquel,Pinho [3]
;
Éva M,Szegö [2]
;
Renato,Martinho [4]
;
Francesca,Munari [5]
;
Diana F,Lázaro [2]
;
Sébastien,Moniot [6]
;
Patrícia,Guerreiro [2]
;
Luis,Fonseca-Ornelas [7]
;
Zrinka,Marijanovic [4]
;
Pedro,Antas [4]
;
Ellen,Gerhardt [2]
;
Francisco Javier,Enguita [4]
;
Bruno,Fauvet [8]
;
Deborah,Penque [9]
;
Teresa Faria,Pais [4]
;
Qiang,Tong [10]
;
Stefan,Becker [7]
;
Sebastian,Kügler [11]
;
Hilal Ahmed,Lashuel [8]
;
Clemens,Steegborn [6]
;
Markus,Zweckstetter [12]
;
Tiago Fleming,Outeiro [13]
作者单位：
CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal.
[1]
Department of Neurodegeneration and Restorative Research, University Medical Center Göttingen, Göttingen, Germany.
[2]
Department of Neurodegeneration and Restorative Research, University Medical Center Göttingen, Göttingen, Germany.;Faculty of Medicine, University of Porto, Porto, Portugal.
[3]
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
[4]
Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
[5]
Department of Biochemistry, University of Bayreuth, Bayreuth, Germany.
[6]
Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
[7]
Laboratory of Molecular and Chemical Biology of Neurodegeneration, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
[8]
Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal.
[9]
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.
[10]
Department of Neurology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
[11]
Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.;Department of Neurology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
[12]
CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal.;Department of Neurodegeneration and Restorative Research, University Medical Center Göttingen, Göttingen, Germany.;Max Planck Institute for Experimental Medicine, Göttingen, Germany.;Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
[13]
医学主题词
1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine);乙酰化作用(Acetylation);动物(Animals);自噬(Autophagy);细胞膜(Cell Membrane);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);疾病模型, 动物(Disease Models, Animal);基因缺失(Gene Deletion);基因敲低技术(Gene Knockdown Techniques);HEK293细胞(HEK293 Cells);人类(Humans);赖氨酸(Lysine);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);突变(Mutation);帕金森病(Parkinson Disease);蛋白质结合(Protein Binding);抗衰老酶2(Sirtuin 2);α突触核蛋白(alpha-Synuclein)
DOI
10.1371/journal.pbio.2000374
PMID
28257421
发布时间
2018-11-13
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