Avoiding the pitfalls of gene set enrichment analysis with SetRank.

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作者： Cedric,Simillion ^[1] ; Robin,Liechti ^[2] ; Heidi E L,Lischer ^[3] ; Vassilios,Ioannidis ^[4] ; Rémy,Bruggmann ^[5]

作者单位： Interfaculty Bioinformatics Unit and SIB Swiss Institute of Bioinformatics, University of Bern, Baltzerstrasse 6, 3012, Berne, Switzerland. cedric.simillion@dkf.unibe.ch. ^[1] Department of Clinical Research, University of Bern, Murtenstrasse 35, 3008, Berne, Switzerland. cedric.simillion@dkf.unibe.ch. ^[2] Vital-IT, SIB Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015, Lausanne, Switzerland. ^[3] Interfaculty Bioinformatics Unit and SIB Swiss Institute of Bioinformatics, University of Bern, Baltzerstrasse 6, 3012, Berne, Switzerland. ^[4] Present Address: URPP Evolution in Action; Institute of Evolutionary Biology and Environmental Studies (IEU), University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. ^[5] SIB Technology, SIB Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015, Lausanne, Switzerland. ^[6] Interfaculty Bioinformatics Unit and SIB Swiss Institute of Bioinformatics, University of Bern, Baltzerstrasse 6, 3012, Berne, Switzerland. remy.bruggmann@bioinformatics.unibe.ch. ^[7]

关键词 Algorithm Functional genomics GSEA Gene set enrichment analysis Pathway analysis R package Sample source bias Web interface