首页> Bioorganic chemistry> Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.

Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.

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第一作者： Xia,Yang

第一单位： Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

作者： Xia,Yang ^[1] ; Xiaoming,Qiang ^[1] ; Yan,Li ^[1] ; Li,Luo ^[1] ; Rui,Xu ^[1] ; Yunxiaozhu,Zheng ^[1] ; Zhongcheng,Cao ^[1] ; Zhenghuai,Tan ^[2] ; Yong,Deng ^[3]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. ^[1] Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China. Electronic address: tanzhh616@163.com. ^[2] Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: dengyong@scu.edu.cn. ^[3]

关键词 AChE inhibitors Alzheimer’s disease Antioxidant MAO-B inhibitors Mannich base derivatives Metal-chelating Pyridoxine-Resveratrol hybrids