New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics.

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作者： Markus,Zeilinger ^[1] ; Florian,Pichler ^[2] ; Lukas,Nics ^[1] ; Wolfgang,Wadsak ^[2] ; Helmut,Spreitzer ^[1] ; Marcus,Hacker ^[1] ; Markus,Mitterhauser ^[3]

作者单位： Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Radiopharmacy and Experimental Nuclear Medicine, Waehringer Guertel 18-20, 1090, Vienna, Austria. ^[1] Faculty of Engineering, University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria. ^[2] Department of Inorganic Chemistry, University of Vienna, Vienna, Austria. ^[3] Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria. ^[4] Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Radiopharmacy and Experimental Nuclear Medicine, Waehringer Guertel 18-20, 1090, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at. ^[5] Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at. ^[6] Ludwig Boltzmann Institute for Applied Diagnostics, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at. ^[7]

关键词 A3R Binding affinity Binding kinetics Cell-based ligand interaction analysis Kinetic competition assay Real-time cell-binding studies

DOI 10.1186/s13550-016-0249-9

PMID 28271461

发布时间 2021-01-09

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