Post-translational modifications in PrP expand the conformational diversity of prions in vivo.

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第一作者： Patricia,Aguilar-Calvo

第一单位： Departments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.

作者： Patricia,Aguilar-Calvo ^[1] ; Xiangzhu,Xiao ^[2] ; Cyrus,Bett ^[1] ; Hasier,Eraña ^[3] ; Katrin,Soldau ^[1] ; Joaquin,Castilla ^[4] ; K Peter R,Nilsson ^[5] ; Witold K,Surewicz ^[2] ; Christina J,Sigurdson ^[6]

作者单位： Departments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA. ^[1] Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44116, USA. ^[2] CIC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, Derio 48160, Spain. ^[3] CIC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, Derio 48160, Spain.;IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain. ^[4] Department of Physics, Chemistry, and Biology, Linköping University, Linköping 581 83, Sweden. ^[5] Departments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.;Department of Pathology, Immunology, and Microbiology, UC Davis, Davis, CA 95616, USA. ^[6]

主题词动物(Animals);小鼠(Mice);表型(Phenotype);妊娠蛋白质类(Pregnancy Proteins);朊病毒病(Prion Diseases);蛋白质构象(Protein Conformation);蛋白质加工, 转译后(Protein Processing, Post-Translational)

DOI 10.1038/srep43295

PMID 28272426

发布时间 2018-11-13

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Post-translational modifications in PrP expand the conformational diversity of prions in vivo.

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Post-translational modifications in PrP expand the conformational diversity of prions in vivo.

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