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Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

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第一作者： Thorsten A,Kirschberg

第一单位： Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA. Electronic address: tkirschberg@gilead.com.

作者： Thorsten A,Kirschberg ^[1] ; Sammy,Metobo ^[2] ; Michael O,Clarke ^[2] ; Vangelis,Aktoudianakis ^[2] ; Darius,Babusis ^[2] ; Ona,Barauskas ^[2] ; Gabriel,Birkus ^[2] ; Thomas,Butler ^[2] ; Daniel,Byun ^[2] ; Gregory,Chin ^[2] ; Edward,Doerffler ^[2] ; Thomas E,Edwards ^[3] ; Martijn,Fenaux ^[2] ; Rick,Lee ^[2] ; Willard,Lew ^[2] ; Michael R,Mish ^[2] ; Eisuke,Murakami ^[2] ; Yeojin,Park ^[2] ; Neil H,Squires ^[2] ; Neeraj,Tirunagari ^[2] ; Ting,Wang ^[2] ; Mark,Whitcomb ^[2] ; Jie,Xu ^[2] ; Huiling,Yang ^[2] ; Hong,Ye ^[2] ; Lijun,Zhang ^[2] ; Todd C,Appleby ^[2] ; Joy Y,Feng ^[2] ; Adrian S,Ray ^[2] ; Aesop,Cho ^[2] ; Choung U,Kim ^[2]

作者单位： Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA. Electronic address: tkirschberg@gilead.com. ^[1] Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA. ^[2] Beryllium, 7869 NE Day Road West, Bainbridge Island, WA 98110, USA. ^[3]

关键词 Antiviral C-nucleoside Hepatitis C NS5B polymerase