Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

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作者： Mark J,McVey ^[1] ; Michael,Kim ^[2] ; Arata,Tabuchi ^[1] ; Victoria,Srbely ^[1] ; Lukasz,Japtok ^[1] ; Christoph,Arenz ^[3] ; Ori,Rotstein ^[4] ; Burkhard,Kleuser ^[1] ; John W,Semple ^[5] ; Wolfgang M,Kuebler ^[3]

作者单位： Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada. ^[1] Departments of Anesthesia and Physiology, University of Toronto, and Department of Anesthesia and Pain Medicine Sickkids Hospital, Toronto, Ontario, Canada. ^[2] Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. ^[3] Institute for Chemistry, Humboldt University, Berlin, Germany. ^[4] Department of Surgery University of Toronto, Toronto, Ontario, Canada. ^[5] Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. ^[6] Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; kueblerw@smh.ca. ^[7] Department of Physiology University of Toronto, Toronto, Ontario, Canada. ^[8] Institute of Physiology, Charité-Univcersitätsmedizin Berlin, Germany; and. ^[9] German Heart Institute, Berlin, Germany. ^[10]

关键词 acid sphingomyelinase ceramide platelets storage transfusion-related acute lung injury