Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.

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作者： Lara,Massai ^[1] ; Luigi,Messori ^[1] ; Nicola,Micale ^[2] ; Tanja,Schirmeister ^[3] ; Louis,Maes ^[4] ; Dolores,Fregona ^[5] ; Maria Agostina,Cinellu ^[6] ; Chiara,Gabbiani ^[7]

作者单位： (MetMed) Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy. ^[1] Laboratory of Nanomedicine, Biomaterials and Heterocyclic Compounds, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, via F. Stagno D'Alcontres 31, 98166, Messina, Italy. ^[2] Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55099, Mainz, Germany. ^[3] Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. ^[4] Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padua, Italy. ^[5] Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100, Sassari, Italy. ^[6] Department of Chemistry and Industrial Chemistry, University of Pisa, via Moruzzi, 13, 56124, Pisa, Italy. chiara.gabbiani@unipi.it. ^[7]

关键词 Cysteine proteases Enzyme inhibition Gold compounds Parasitic protozoa