Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study.

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作者： Jeffrey A,Sparks ^[1] ; Medha,Barbhaiya ^[2] ; Elizabeth W,Karlson ^[3] ; Susan Y,Ritter ^[3] ; Soumya,Raychaudhuri ^[4] ; Cassandra C,Corrigan ^[5] ; Fengxin,Lu ^[5] ; Jacob,Selhub ^[6] ; Daniel I,Chasman ^[7] ; Nina P,Paynter ^[7] ; Paul M,Ridker ^[7] ; Daniel H,Solomon ^[3]

作者单位： Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: jsparks@bwh.harvard.edu. ^[1] Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: mbarbhaiya@partners.org. ^[2] Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA; Harvard Medical School, Boston, MA. ^[3] Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA; Harvard Medical School, Boston, MA; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA. ^[4] Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA. ^[5] Jean Mayer USDA, Human Nutrition Center on Aging, Tufts University, Boston, MA. ^[6] Harvard Medical School, Boston, MA; Department of Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women׳s Hospital, Boston, MA. ^[7]

关键词 Genetics Methotrexate Pharmacovigilance Polyglutamate Toxicity