首页> Journal of medicinal chemistry> Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

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第一作者： Simon,Planken

第一单位： Wuxi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.

作者： Simon,Planken ^[1] ; Douglas C,Behenna ^[1] ; Sajiv K,Nair ^[1] ; Theodore O,Johnson ^[1] ; Asako,Nagata ; Chau,Almaden ; Simon,Bailey ; T Eric,Ballard ; Louise,Bernier ; Hengmiao,Cheng ; Sujin,Cho-Schultz ; Deepak,Dalvie ; Judith G,Deal ; Dac M,Dinh ; Martin P,Edwards ; Rose Ann,Ferre ; Ketan S,Gajiwala ; Michelle,Hemkens ; Robert S,Kania ; John C,Kath ; Jean,Matthews ; Brion W,Murray ; Sherry,Niessen ; Suvi T M,Orr ; Mason,Pairish ; Neal W,Sach ; Hong,Shen ; Manli,Shi ; James,Solowiej ; Khanh,Tran ; Elaine,Tseng ; Paolo,Vicini ; Yuli,Wang ; Scott L,Weinrich ; Ru,Zhou ; Michael,Zientek ; Longqing,Liu ; Yiqin,Luo ; Shuibo,Xin ; Chengyi,Zhang ; Jennifer,Lafontaine

作者单位： Wuxi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China. ^[1]