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A Systematic Study of Molecular Interactions of Anionic Drugs with a Dimethylaminoethyl Methacrylate Copolymer Regarding Solubility Enhancement.

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第一作者： Wiebke,Saal

第一单位： Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland , Gründenstrasse 40, 4132 Muttenz, Switzerland.;Institute of Pharmaceutical Technology, University of Basel , Klingelbergstrasse 50, 4056 Basel, Switzerland.

作者： Wiebke,Saal ^[1] ; Alfred,Ross ^[2] ; Nicole,Wyttenbach ^[2] ; Jochem,Alsenz ^[2] ; Martin,Kuentz ^[3]

作者单位： Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland , Gründenstrasse 40, 4132 Muttenz, Switzerland.;Institute of Pharmaceutical Technology, University of Basel , Klingelbergstrasse 50, 4056 Basel, Switzerland. ^[1] Roche Pharmaceutical Research & Early Development, Pre-Clinical CMC, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[2] Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland , Gründenstrasse 40, 4132 Muttenz, Switzerland. ^[3]

关键词 acidic drugs nuclear magnetic resonance (NMR) spectroscopy polymer?drug interaction solubility enhancement