HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

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作者： Priyanka,Banerjee ^[1] ; Abhijit,Chakraborty ^[2] ; Rajiv Kumar,Mondal ^[1] ; Mousumi,Khatun ^[1] ; Somenath,Datta ^[1] ; Kausik,Das ^[3] ; Pratap,Pandit ^[1] ; Souvik,Mukherjee ^[4] ; Soma,Banerjee ^[1] ; Saurabh,Ghosh ^[5] ; Saikat,Chakrabarti ^[2] ; Abhijit,Chowdhury ^[3] ; Simanti,Datta ^[1]

作者单位： Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India. ^[1] Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India. ^[2] Department of Hepatology, School of Digestive &Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India. ^[3] BioMedical Genomics Centre, National Institute of Biomedical Genomics, West Bengal, India. ^[4] Human Genetics Unit, Indian Statistical Institute, Kolkata, India. ^[5]

主题词成年人(Adult);氨基酸取代(Amino Acid Substitution);人口统计学(Demography);表位, B淋巴细胞(Epitopes, B-Lymphocyte);基因, 病毒(Genes, Viral);基因型(Genotype);乙型肝炎病毒(Hepatitis B virus);乙型肝炎, 慢性(Hepatitis B, Chronic);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);拉米夫定(Lamivudine);突变(Mutation);RNA指导的DNA聚合酶(RNA-Directed DNA Polymerase);治疗结果(Treatment Outcome);病毒蛋白质类(Viral Proteins)

DOI 10.1038/srep44742

PMID 28303969

发布时间 2018-11-13

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HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

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HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

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