Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

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作者： Joshua D,Stender ^[1] ; Jerome C,Nwachukwu ^[2] ; Irida,Kastrati ^[3] ; Yohan,Kim ^[4] ; Tobias,Strid ^[1] ; Maayan,Yakir ^[1] ; Sathish,Srinivasan ^[2] ; Jason,Nowak ^[2] ; Tina,Izard ^[2] ; Erumbi S,Rangarajan ^[2] ; Kathryn E,Carlson ^[5] ; John A,Katzenellenbogen ^[5] ; Xin-Qiu,Yao ^[6] ; Barry J,Grant ^[6] ; Hon S,Leong ^[7] ; Chin-Yo,Lin ^[8] ; Jonna,Frasor ^[3] ; Kendall W,Nettles ^[2] ; Christopher K,Glass ^[9]

作者单位： Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ^[1] Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. ^[2] Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA. ^[3] Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada. ^[4] Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA. ^[5] Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[6] Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada. ^[7] Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. ^[8] Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ckg@ucsd.edu. ^[9]

关键词 breast cancer crystallography cytokines drug resistance estrogen receptor inflammation tamoxifen