Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.

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第一作者： Md Morshedul,Alam

第一单位： From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.

作者： Md Morshedul,Alam ^[1] ; Keito,Okazaki ^[1] ; Linh Thi Thao,Nguyen ^[1] ; Nao,Ota ^[1] ; Hiroshi,Kitamura ^[1] ; Shohei,Murakami ^[1] ; Hiroki,Shima ^[2] ; Kazuhiko,Igarashi ^[2] ; Hiroki,Sekine ^[3] ; Hozumi,Motohashi ^[4]

作者单位： From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575. ^[1] the Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, and.;CREST, AMED, Sendai, Miyagi 980-8575, Japan. ^[2] From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, sekine@med.tohoku.ac.jp. ^[3] From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, hozumim@med.tohoku.ac.jp. ^[4]

关键词 Nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2)electrophile gene transcription glucocorticoid receptor histone acetylation oxidative stress