Aortic calcified particles modulate valvular endothelial and interstitial cells.

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作者： Nicole C A,van Engeland ^[1] ; Sergio,Bertazzo ^[2] ; Padmini,Sarathchandra ^[3] ; Ann,McCormack ^[3] ; Carlijn V C,Bouten ^[4] ; Magdi H,Yacoub ^[3] ; Adrian H,Chester ^[3] ; Najma,Latif ^[5]

作者单位： Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK; Eindhoven University of Technology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, 5600 MB Eindhoven, the Netherlands. ^[1] University College London, Department of Medical Physics & Biomedical Engineering, Malet Place Engineering Building, London, WC1E 6BT, UK. ^[2] Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK. ^[3] Eindhoven University of Technology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, 5600 MB Eindhoven, the Netherlands. ^[4] Imperial College London, Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK. Electronic address: n.latif@imperial.ac.uk. ^[5]

关键词 Calcified particles Endothelial-to-mesenchymal transformation Osteogenesis Valve endothelial cells Valve interstitial cells

主题词肌动蛋白类(Actins);青少年(Adolescent);成年人(Adult);老年人(Aged);抗原, CD(Antigens, CD);主动脉疾病(Aortic Diseases);主动脉瓣(Aortic Valve);细胞凋亡(Apoptosis);钙黏着糖蛋白类(Cadherins);钙(Calcium);病例对照研究(Case-Control Studies);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);儿童(Child);儿童, 学龄前(Child, Preschool);内皮细胞(Endothelial Cells);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);心脏瓣膜疾病(Heart Valve Diseases);人类(Humans);婴儿(Infant);婴儿, 新生(Infant, Newborn);男(雄)性(Male);中年人(Middle Aged);骨桥蛋白质(Osteopontin);粒子大小(Particle Size);表型(Phenotype);时间因素(Time Factors);青年人(Young Adult);von Willebrand因子(von Willebrand Factor)

DOI 10.1016/j.carpath.2017.02.006

PMID 28319833

发布时间 2017-12-18

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Cardiovascular pathology

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Aortic calcified particles modulate valvular endothelial and interstitial cells.

Cardiovascular pathology

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Aortic calcified particles modulate valvular endothelial and interstitial cells.

Cardiovascular pathology

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Cardiovascular pathology

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