Genetic epistasis regulates amyloid deposition in resilient aging.

导出 OA

翻译打印收藏纠错

作者： Daniel,Felsky ^[1] ; Jishu,Xu ^[2] ; Lori B,Chibnik ^[2] ; Julie A,Schneider ^[3] ; Jo,Knight ^[4] ; James L,Kennedy ^[5] ; Alzheimer's Disease Neuroimaging Initiative ^[3] ; David A,Bennett ^[2] ; Philip L,De Jager ^[6] ; Aristotle N,Voineskos

作者单位： Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. ^[1] Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. ^[2] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. ^[3] Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Data Science Institute and the Medical School, Lancaster University, Bailrigg, Lancaster, UK. ^[4] Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. ^[5] Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: aristotle.voineskos@camh.ca. ^[6]

关键词 Alzheimer's disease Amyloid BDNF Epistasis PET imaging RNA sequencing SORL1