Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors.-论文-万方医学网

作者： Young-Hwan,Jung ^[1] ; Yeo Ok,Kim ^[2] ; Hai,Lin ^[2] ; Joong-Heui,Cho ^[1] ; Jin-Hee,Park ^[3] ; So-Deok,Lee ^[1] ; Jinsu,Bae ^[4] ; Koon Mook,Kang ^[5] ; Yoon-Gyoon,Kim ^[1] ; Ae Nim,Pae ^[1] ; Hyojin,Ko ^[1] ; Chul-Seung,Park ^[3] ; Myung Ha,Yoon ; Yong-Chul,Kim

作者单位： School of Life Sciences, Gwangju Institute of Science and Technology (GIST) , Gwangju 500-712, Republic of Korea. ^[1] New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) , 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea. ^[2] Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST) , Gwangju 500-712, Republic of Korea. ^[3] College of Pharmacy, Dankook University , Cheonan 330-714, Republic of Korea. ^[4] Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology , PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea. ^[5]

主题词镇痛药, 非麻醉(Analgesics, Non-Narcotic);动物(Animals);抗肿瘤药(Antineoplastic Agents);脑(Brain);疾病模型, 动物(Disease Models, Animal);HEK293细胞(HEK293 Cells);人类(Humans);结扎术(Ligation);男(雄)性(Male);小鼠(Mice);分子结构(Molecular Structure);神经痛(Neuralgia);卵母细胞(Oocytes);膜片钳术(Patch-Clamp Techniques);通透性(Permeability);嘌呤能P2X受体拮抗剂(Purinergic P2X Receptor Antagonists);吡啶类(Pyridines);大鼠(Rats);受体, 嘌呤能P2X3(Receptors, Purinergic P2X3);脊神经(Spinal Nerves);构效关系(Structure-Activity Relationship);爪蟾属(Xenopus)

DOI 10.1021/acschemneuro.6b00401

PMID 28323403

发布时间 2018-02-23

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Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors.

ACS chemical neuroscience

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ACS chemical neuroscience

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Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors.

ACS chemical neuroscience

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ACS chemical neuroscience

相关期刊

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