miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.-论文-万方医学网

作者： Daijiro,Hori ^[1] ; Brittany,Dunkerly-Eyring ^[2] ; Yohei,Nomura ^[3] ; Debjit,Biswas ^[4] ; Jochen,Steppan ^[1] ; Jorge,Henao-Mejia ^[2] ; Hideo,Adachi ^[4] ; Lakshmi,Santhanam ^[2] ; Dan E,Berkowitz ^[5] ; Charles,Steenbergen ^[3] ; Richard A,Flavell ^[2] ; Samarjit,Das ^[2]

作者单位： Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America. ^[1] Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America. ^[2] Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan. ^[3] Department of Cardiovascular Pathology, Ross Research Building, Johns Hopkins University, Baltimore, Maryland, United States of America. ^[4] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America. ^[5]

主题词衰老(Aging);血管紧张素Ⅱ(Angiotensin II);动物(Animals);抗高血压药(Antihypertensive Agents);主动脉(Aorta);血压(Blood Pressure);心血管疾病(Cardiovascular Diseases);内皮细胞(Endothelial Cells);细胞外基质(Extracellular Matrix);高血压(Hypertension);洛沙坦(Losartan);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);微RNAs(MicroRNAs);一氧化氮(Nitric Oxide);Smad2蛋白质(Smad2 Protein);Smad3蛋白质(Smad3 Protein);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1371/journal.pone.0174108

PMID 28323879

发布时间 2022-03-18

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miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

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miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

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