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Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.

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第一作者： Armando,Lagrutta

第一单位： Dept. Safety and Exploratory Pharmacology, Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA.

作者： Armando,Lagrutta ^[1] ; Christopher P,Regan ^[1] ; Haoyu,Zeng ^[1] ; John P,Imredy ^[1] ; Kenneth,Koeplinger ^[2] ; Pierre,Morissette ^[1] ; Liping,Liu ^[3] ; Gordon,Wollenberg ^[4] ; Christopher,Brynczka ^[5] ; José,Lebrón ^[3] ; Joseph,DeGeorge ^[6] ; Frederick,Sannajust ^[1]

作者单位： Dept. Safety and Exploratory Pharmacology, Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA. ^[1] Dept. Preclinical ADME, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, MRL, Merck &Co., West Point, PA, USA. ^[2] Dept. Investigative Laboratory Sciences, Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA. ^[3] Dept. Pathology, Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA. ^[4] Dept. Program Development, Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA. ^[5] Safety Assessment and Laboratory Animal Resources, MRL, Merck &Co., West Point, PA, USA. ^[6]