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Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

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第一作者: Young Seok,Ju
第一单位: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.;Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
作者单位: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.;Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. [1] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. [2] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.;European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK. [3] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.;Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. [4] Genomic Mutation and Genetic Disease, Wellcome Trust Sanger Institute, Hinxton, UK. [5] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.;Oxford Big Data Institute and Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, UK. [6] Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [7] Institute of Clinical Medicine, Campus at Akershus University Hospital, University of Oslo, Lørenskog, Norway. [8] King's Health Partners Cancer Biobank, Guy's Hospital, King's College London School of Medicine, London, UK. [9] Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK. [10] BioCare, Strategic Cancer Research Program, Lund, Sweden.;CREATE Health, Strategic Centre for Translational Cancer Research, Lund, Sweden.;Department of Oncology and Pathology, Lund University Cancer Center, Lund, Sweden. [11] Radboud University Medical Center, Nijmegen, The Netherlands. [12] Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. [13] SingHealth Duke-NUS Breast Centre, Division of Surgical Oncology, National Cancer Centre Singapore, Department of General Surgery, Singapore General Hospital, Singapore. [14] Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK. [15] Breast Cancer Now Research Unit, King's College London, London SE1 9RT, UK.;Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London SW3 6JB, UK. [16] Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [17] Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA. [18] Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. [19] Institut Jules Bordet, Brussels, Belgium. [20] Section of Oncology, Department of Clinical Science, University of Bergen, Bergen, Norway.;Department of Oncology, Haukeland University Hospital, Bergen, Norway. [21] Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. [22] University of Queensland, School of Medicine, Brisbane, Australia.;Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.;University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia. [23] Cancer Research Laboratory, University of Iceland, Reykjavik, Iceland. [24] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.;The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. [25] Sibley Pathology Department, Johns Hopkins Medicine, Washington DC 20016, USA. [26] Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [27] Plateforme Gilles Thomas, Synergie Lyon Cancer, Centre Léon Bérard, Lyon Cedex 08, France. [28]
DOI 10.1038/nature21703
PMID 28329761
发布时间 2025-05-30
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