High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

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作者： Seth A,Ament ^[1] ; Jocelynn R,Pearl ^[2] ; Andrea,Grindeland ^[1] ; Jason,St Claire ^[3] ; John C,Earls ^[4] ; Marina,Kovalenko ^[5] ; Tammy,Gillis ^[1] ; Jayalakshmi,Mysore ^[6] ; James F,Gusella ^[5] ; Jong-Min,Lee ^[5] ; Seung,Kwak ^[5] ; David,Howland ^[5] ; Min Young,Lee ^[5] ; David,Baxter ^[7] ; Kelsey,Scherler ^[7] ; Kai,Wang ^[1] ; Donald,Geman ^[1] ; Jeffrey B,Carroll ^[1] ; Marcy E,MacDonald ^[1] ; George,Carlson ^[8] ; Vanessa C,Wheeler ^[9] ; Nathan D,Price ^[5] ; Leroy E,Hood ^[4]

作者单位： Institute for Systems Biology, Seattle, WA, USA. ^[1] Institute for Genome Sciences and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. ^[2] Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA. ^[3] McLaughlin Research Institute, Great Falls, MT, USA. ^[4] Center for Human Genetic Research, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. ^[5] Department of Computer Science, University of Washington, Seattle, WA, USA. ^[6] CHDI Management/CHDI Foundation, Princeton, NJ, USA. ^[7] Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA. ^[8] Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA. ^[9]