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Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

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第一作者： Saikat,Chowdhury

第一单位： Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

作者： Saikat,Chowdhury ^[1] ; Joshua,Carter ^[2] ; MaryClare F,Rollins ^[2] ; Sarah M,Golden ^[2] ; Ryan N,Jackson ^[2] ; Connor,Hoffmann ^[2] ; Lyn'Al,Nosaka ^[1] ; Joseph,Bondy-Denomy ^[3] ; Karen L,Maxwell ^[4] ; Alan R,Davidson ^[5] ; Elizabeth R,Fischer ^[6] ; Gabriel C,Lander ^[7] ; Blake,Wiedenheft ^[8]

作者单位： Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA. ^[1] Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. ^[2] Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA. ^[3] Department of Biochemistry, University of Toronto, Toronto, ON, Canada. ^[4] Department of Biochemistry, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. ^[5] Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA. ^[6] Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: glander@scripps.edu. ^[7] Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: bwiedenheft@gmail.com. ^[8]

关键词 Acr CRISPR CRISPR-Cas Cas Csy anti-CRISPRs crRNA cryo-EM cryo-electron microscopy type I-F