Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model.

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第一作者： Xin,Wei

第一单位： Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.

作者： Xin,Wei ^[1] ; Fei,Li ^[1] ; Gang,Zhao ^[1] ; Yashpal Singh,Chhonker ^[1] ; Christine,Averill ^[2] ; Josselyn,Galdamez ^[2] ; P Edward,Purdue ^[2] ; Xiaoyan,Wang ^[1] ; Edward V,Fehringer ^[3] ; Kevin L,Garvin ^[3] ; Steven R,Goldring ^[2] ; Yazen,Alnouti ^[1] ; Dong,Wang ^[4]

作者单位： Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States. ^[1] Hospital for Special Surgery , New York, New York 10021, United States. ^[2] Department of Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States. ^[3] Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.;Department of Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States. ^[4]

关键词 ELVIS HPMA copolymer biodistribution dexamethasone implant loosening inflammation targeting pharmacokinetics