Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.

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作者： Toshiaki,Takahashi ^[1] ; Takeharu,Yamanaka ^[2] ; Takashi,Seto ^[3] ; Hideyuki,Harada ^[4] ; Hiroshi,Nokihara ^[5] ; Hideo,Saka ^[6] ; Makoto,Nishio ^[7] ; Hiroyasu,Kaneda ^[8] ; Koichi,Takayama ^[9] ; Osamu,Ishimoto ^[10] ; Koji,Takeda ^[11] ; Hiroshige,Yoshioka ^[12] ; Motoko,Tachihara ^[13] ; Hiroshi,Sakai ^[14] ; Koichi,Goto ^[15] ; Nobuyuki,Yamamoto ^[16]

作者单位： Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan. ^[1] Department of Biostatistics, Yokohama City University, Yokohama, Japan. ^[2] Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan. ^[3] Division of Radiation Therapy, Shizuoka Cancer Center, Shizuoka, Japan. ^[4] Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan. ^[5] Department of Respiratory Medicine and Medical Oncology, National Hospital Organization Nagoya Medical Center, Aichi, Japan. ^[6] Department of Thoracic Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan. ^[7] Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan. ^[8] Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan. ^[9] Department of Pulmonary Medicine, Sendai Kousei Hospital, Miyagi, Japan. ^[10] Department of Medical Oncology, Osaka City General Hospital, Osaka, Japan. ^[11] Department of Respiratory Medicine, Kurashiki Central Hospital, Okayama, Japan. ^[12] Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. ^[13] Department of Thoracic Oncology, Saitama Cancer Center, Saitama, Japan. ^[14] Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. ^[15] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: nbyamamo@wakayama-med.ac.jp. ^[16]