miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.

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作者： Jie-Jie,Zhang ^[1] ; Wei-Qi,Liu ^[2] ; Jing-Jie,Peng ^[3] ; Qi-Lin,Ma ^[2] ; Jun,Peng ^[4] ; Xiu-Ju,Luo ^[5]

作者单位： Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. ^[1] Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. ^[2] Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, China. ^[3] Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Electronic address: Junpeng@csu.edu.cn. ^[4] Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, China. Electronic address: xjluo22@csu.edu.cn. ^[5]

关键词 Dynamin-related protein 1 Hyperlipidemia Senescence miR-203a-3p miR-21-5p