PLP and GABA trigger GabR-mediated transcription regulation in <i>Bacillus subtilis</i> via external aldimine formation.

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作者： Rui,Wu ^[1] ; Ruslan,Sanishvili ^[2] ; Boris R,Belitsky ^[3] ; Jose I,Juncosa ^[4] ; Hoang V,Le ^[5] ; Helaina J S,Lehrer ^[4] ; Michael,Farley ^[5] ; Richard B,Silverman ^[6] ; Gregory A,Petsko ^[1] ; Dagmar,Ringe ^[4] ; Dali,Liu ^[5]

作者单位： Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660. ^[1] GM/CA@APS, The X-Ray Science Division, the Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439. ^[2] Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111. ^[3] Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL 60208-3113. ^[4] Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL 60208-3113. ^[5] Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454. ^[6] Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454; dliu@luc.edu gpetsko@med.cornell.edu. ^[7] Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065. ^[8] Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660; dliu@luc.edu gpetsko@med.cornell.edu. ^[9]

关键词 GabR MocR PLP external aldimine transcription activation