Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.

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第一作者： Valentina,Klaus

第一单位： Computational Discovery Research, Institute for Diabetes and Obesity, Helmholtz Diabetes Center & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, Germany.

作者： Valentina,Klaus ^[1] ; Heinke,Bastek ^[2] ; Katja,Damme ^[3] ; Leonard B,Collins ^[3] ; Roland,Frötschl ^[4] ; Norbert,Benda ^[4] ; Dominik,Lutter ^[1] ; Heidrun,Ellinger-Ziegelbauer ^[5] ; James A,Swenberg ^[3] ; Daniel R,Dietrich ^[2] ; Kerstin,Stemmer ^[6]

作者单位： Computational Discovery Research, Institute for Diabetes and Obesity, Helmholtz Diabetes Center & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, Germany. ^[1] Human and Environmental Toxicology, University of Konstanz, Konstanz, Germany. ^[2] Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. ^[3] Federal Institute for Drugs and Medical Devices, Bonn, Germany. ^[4] Investigational Toxicology, DD-ED-Toxicology, Bayer AG, Wuppertal, Germany. ^[5] Metabolism and Cancer, Institute for Diabetes and Obesity, Helmholtz Diabetes Center & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, Germany. kerstin.stemmer@helmholtz-muenchen.de. ^[6]

关键词 Biomarkers of effect Biomarkers of exposure DNA adducts Eker rat Kidney cancer Methylazoxymethanol acetate