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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.

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第一作者： Verena,Zuber

第一单位： Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway.;NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.;European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

作者： Verena,Zuber ^[1] ; Francesco,Bettella ^[2] ; Aree,Witoelar ^[2] ; PRACTICAL Consortium ^[2] ; CRUK GWAS ^[3] ; BCAC Consortium ^[4] ; TRICL Consortium ; Ole A,Andreassen ; Ian G,Mills ; Alfonso,Urbanucci

作者单位： Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway.;NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.;European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. ^[1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. ^[2] Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway.;Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.;PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast, UK. ^[3] Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway. alfonsourbanucci@gmail.com.;Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. alfonsourbanucci@gmail.com. ^[4]

关键词 BRD4 Chromatin Functional annotation Genome-wide association studies Prostate cancer risk Risk loci SNPs breast cancer risk schizophrenia super-enhancer