The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

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作者： Guang,Yang ^[1] ; Xinyu,Weng ^[1] ; Yuhao,Zhao ^[2] ; Xinjian,Zhang ^[3] ; Yuanping,Hu ^[1] ; Xin,Dai ^[1] ; Peng,Liang ^[1] ; Peng,Wang ^[1] ; LeiLei,Ma ^[1] ; Xiaolei,Sun ^[2] ; Lei,Hou ^[2] ; Huihui,Xu ^[3] ; Mingming,Fang ^[3] ; Yuehua,Li ^[1] ; Thomas,Jenuwein ^[1] ; Yong,Xu ^[4] ; Aijun,Sun ^[1]

作者单位： Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathophysiology, Nanjing Medical University, Nanjing 211166, China. ^[1] Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, China. ^[2] Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China. ^[3] Department of Nursing, Jiangsu Jiankang Vocational College, Nanjing 210029, china. ^[4] Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany. ^[5]

主题词动物(Animals);动物, 新生(Animals, Newborn);强心药(Cardiotonic Agents);基因沉默(Gene Silencing);组蛋白类(Histones);赖氨酸(Lysine);甲基转移酶类(Methyltransferases);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);心肌梗死(Myocardial Infarction);肌细胞, 心脏(Myocytes, Cardiac);氧化性应激(Oxidative Stress);哌嗪类(Piperazines);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);活性氧(Reactive Oxygen Species);阻遏蛋白质类(Repressor Proteins);抗衰老酶1(Sirtuin 1);转录, 遗传(Transcription, Genetic);增量调节(Up-Regulation)

DOI 10.1038/ncomms14941

PMID 28361889

发布时间 2018-11-13

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Nature communications

2017年8卷

14941页

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The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

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The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

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