Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB.

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作者： Noemi A,Guadagno ^[1] ; Claudia,Moriconi ^[1] ; Valerio,Licursi ^[2] ; Emanuela,D'Acunto ^[1] ; Paola S,Nisi ^[1] ; Nicoletta,Carucci ^[1] ; Antonella,De Jaco ^[1] ; Emanuele,Cacci ^[1] ; Rodolfo,Negri ^[3] ; Giuseppe,Lupo ^[4] ; Elena,Miranda ^[5]

作者单位： Dpt. of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Italy. ^[1] Dpt. of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Italy; Institute for Systems Analysis and Computer Science 'Antonio Ruberti', National Research Council, Rome, Italy. ^[2] Dpt. of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Italy; Institute of Biology and Molecular Pathology (IBPM), National Research Council, Rome, Italy. ^[3] Dpt. of Chemistry, Sapienza University of Rome, Italy. Electronic address: giuseppe.lupo@uniroma1.it. ^[4] Dpt. of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Italy; Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Rome, Italy. Electronic address: mariaelena.mirandabanos@uniroma1.it. ^[5]

关键词 Familial encephalopathy with neuroserpin inclusion bodies Neural progenitor cells Neurodegeneration Neurons Neuroserpin Oxidative stress Protein conformational disease Serpin polymers