Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability.

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第一作者： Jarosław,Sławiński

第一单位： Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address: jaroslaw@gumed.edu.pl.

作者： Jarosław,Sławiński ^[1] ; Krzysztof,Szafrański ^[2] ; Aneta,Pogorzelska ^[2] ; Beata,Żołnowska ^[2] ; Anna,Kawiak ^[3] ; Katarzyna,Macur ^[4] ; Mariusz,Belka ^[5] ; Tomasz,Bączek ^[5]

作者单位： Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address: jaroslaw@gumed.edu.pl. ^[1] Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. ^[2] Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, ul. Abrahama 58, 80-307 Gdańsk, Poland; Laboratory of Human Physiology, Medical University of Gdańsk, ul. Tuwima 15, 80-210 Gdańsk, Poland. ^[3] Laboratory of Mass Spectrometry, Core Facility Laboratories, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, ul. Abrahama 58, 80-307 Gdańsk, Poland. ^[4] Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. ^[5]

关键词 1,3,4-Oxadiazole 2-Mercaptobenzenesulfonamide Anticancer activity Metabolic stability QSAR Synthesis