Identification and characterization of guanosine 5'-monophosphate reductase of Trypanosoma congolense as a drug target.

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作者： Albertus Eka Yudistira,Sarwono ^[1] ; Keisuke,Suganuma ^[2] ; Shinya,Mitsuhashi ^[1] ; Tadashi,Okada ^[3] ; Simon Peter,Musinguzi ^[4] ; Kengo,Shigetomi ^[1] ; Noboru,Inoue ^[5] ; Makoto,Ubukata ^[6]

作者单位： Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan. ^[1] National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan. ^[2] National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan; Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. ^[3] National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan. ^[4] Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan. ^[5] Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan. Electronic address: m-ub@for.agr.hokudai.ac.jp. ^[6]

关键词 African trypanosomosis GMP reductase Purine metabolic pathway Trypanosoma congolense