Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement.

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作者： Ju-Young,Kim ^[1] ; Myeung Su,Lee ^[2] ; Jong Min,Baek ^[3] ; Jongtae,Park ^[4] ; Byung-Soo,Youn ^[5] ; Jaemin,Oh ^[6]

作者单位： Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. ^[1] Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. ^[2] Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. ^[3] Department of Neurosurgery, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. ^[4] Biomedical Research Center, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojinsunwhando-ro, Dong-Ku, Ulsan 682-714, Republic of Korea; OsteoNeuroGen 40 MiKeum-ro, Bundang, Kyunggi 461-871, Republic of Korea. ^[5] Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. ^[6]

关键词 ALP, alkaline phosphatase Actin depolymerization;BMCs, bone marrow cells BMMs, bone marrow macrophages Cytoskeletal rearrangement FBS, fetal bovine serum H&E, hematoxylin and eosin HDACis, Histone deacetylase inhibitors LPS, lipopolysaccharide M-CSF, macrophage colony-stimulating factor MNCs, multinucleated cells NFATc1, nuclear factor of activated T cells c1 OB, osteoblasts OC, osteoclasts OVX, ovariectomized Osteoclastogenesis;PGE2, prostaglandin E2 RANK, the receptor activator of nuclear factor κB RANKL, RANK ligand SD, standard deviation SE, standard error SOST, sclerostin TBST, tris-buffered saline contacting 0.1 Tween-20 TRAP, tartrate-resistant acid phosphate Transcriptional repression;XTT, sodium3’-[1-(phenyl-aminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)α-MEM, α-minimum essential medium μCT, micro-computed tomography

DOI 10.1016/j.bonr.2015.10.003

PMID 28377971

发布时间 2020-09-30

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Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement.

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Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement.

Bone reports

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