换一批
换一批Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.
作者：
Claire,Vennin [1]
;
Venessa T,Chin [2]
;
Sean C,Warren [1]
;
Morghan C,Lucas [2]
;
David,Herrmann [1]
;
Astrid,Magenau [2]
;
Pauline,Melenec [1]
;
Stacey N,Walters [2]
;
Gonzalo,Del Monte-Nieto [1]
;
James R W,Conway [2]
;
Max,Nobis [1]
;
Amr H,Allam [2]
;
Rachael A,McCloy [1]
;
Nicola,Currey [2]
;
Mark,Pinese [1]
;
Alice,Boulghourjian [2]
;
Anaiis,Zaratzian [2]
;
Arne A S,Adam [3]
;
Celine,Heu [1]
;
Adnan M,Nagrial [2]
;
Angela,Chou [1]
;
Angela,Steinmann [2]
;
Alison,Drury [1]
;
Danielle,Froio [2]
;
Marc,Giry-Laterriere [1]
;
Nathanial L E,Harris [2]
;
Tri,Phan [1]
;
Rohit,Jain [2]
;
Wolfgang,Weninger [1]
;
Ewan J,McGhee [2]
;
Renee,Whan [1]
;
Amber L,Johns [1]
;
Jaswinder S,Samra [3]
;
Lorraine,Chantrill [4]
;
Anthony J,Gill [1]
;
Maija,Kohonen-Corish [1]
;
Richard P,Harvey [2]
;
Andrew V,Biankin [5]
;
Australian Pancreatic Cancer Genome Initiative (APGI) [1]
;
T R Jeffry,Evans [1]
;
Kurt I,Anderson [1]
;
Shane T,Grey [1]
;
Christopher J,Ormandy [2]
;
David,Gallego-Ortega [1]
;
Yingxiao,Wang [6]
;
Michael S,Samuel [1]
;
Owen J,Sansom [2]
;
Andrew,Burgess [7]
;
Thomas R,Cox [8]
;
Jennifer P,Morton [7]
;
Marina,Pajic [8]
;
Paul,Timpson [9]
作者单位：
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.
[1]
St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2010, Australia.
[2]
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales 2010, Australia.
[3]
Biomedical Imaging Facility, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.
[4]
Department of Pathology, St. Vincent's Hospital, Sydney, New South Wales 2010, Australia.
[5]
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales 2522, Australia.
[6]
Immune Imaging Program, Centenary Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
[7]
University of Sydney Medical School, Sydney, New South Wales 2006, Australia.
[8]
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
[9]
Cancer Research UK Beatson Institute, Glasgow, Scotland G61 BD, U.K.
[10]
Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research and Royal North Shore Hospital, Sydney, New South Wales 2065, Australia.
[11]
University of Sydney, Sydney, New South Wales 2006, Australia.
[12]
Australian Pancreatic Cancer Genome Initiative.
[13]
Department of Surgery, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia.
[14]
Macarthur Cancer Therapy Centre, Campbelltown Hospital, Sydney, New South Wales 2560, Australia.
[15]
School of Medicine, Western Sydney University, Penrith, Sydney, New South Wales 2751, Australia.
[16]
School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, New South Wales 2052, Australia.
[17]
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Scotland G61 BD, U.K.
[18]
West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Scotland G61 BD, U.K.
[19]
Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, San Diego, CA 92121, USA.
[20]
Centre for Cancer Biology, SA Pathology and University of South Australia School of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia.
[21]
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia. m.pajic@garvan.org.au p.timpson@garvan.org.au.
[22]
主题词
1-(5-异喹啉磺酰基)-2-甲基哌嗪(1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine);动物(Animals);抗肿瘤药(Antineoplastic Agents);生物传感技术(Biosensing Techniques);CDC2蛋白激酶(CDC2 Protein Kinase);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);胶原(Collagen);脱氧胞苷(Deoxycytidine);疾病恶化(Disease Progression);细胞外基质(Extracellular Matrix);人类(Humans);肝(Liver);小鼠(Mice);肿瘤侵润(Neoplasm Invasiveness);肿瘤转移(Neoplasm Metastasis);胰腺肿瘤(Pancreatic Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);信号传导(Signal Transduction);治疗结果(Treatment Outcome);rho相关激酶类(rho-Associated Kinases);src族激酶类(src-Family Kinases)
DOI
10.1126/scitranslmed.aai8504
PMID
28381539
发布时间
2024-02-10
- 浏览24
Science translational medicine
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