Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9.

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作者： Hao,Li ^[1] ; Chunyu,Sheng ^[1] ; Shan,Wang ^[1] ; Lang,Yang ^[1] ; Yuan,Liang ^[1] ; Yong,Huang ^[2] ; Hongbo,Liu ^[1] ; Peng,Li ^[1] ; Chaojie,Yang ^[1] ; Xiaoxia,Yang ^[1] ; Leili,Jia ^[1] ; Jing,Xie ^[1] ; Ligui,Wang ^[1] ; Rongzhang,Hao ^[1] ; Xinying,Du ^[1] ; Dongping,Xu ^[3] ; Jianjun,Zhou ^[4] ; Mingzhen,Li ^[5] ; Yansong,Sun ^[1] ; Yigang,Tong ^[2] ; Qiao,Li ^[6] ; Shaofu,Qiu ^[1] ; Hongbin,Song ^[1]

作者单位： Center for Infectious Disease Control, Institute of Disease Control and Prevention, Academy of Military Medical Sciences Beijing, China. ^[1] State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology Beijing, China. ^[2] Research Centre for Liver Failure, Beijing 302nd Hospital Beijing, China. ^[3] Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of MedicineShanghai, China; Gladcan Consulting CompanyBeijing, China. ^[4] Research and Development Department, Beijing Center for Physical and Chemical Analysis Beijing, China. ^[5] Department of Surgery, University of Michigan Ann Arbor, MI, USA. ^[6]

关键词 CRISPR-Cas9 HBV cccDNA hepatitis B virus integrated HBV DNA whole genome sequencing