Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling.

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作者： Nasra,Yasin ^[1] ; Leo,Veenman ^[2] ; Sukhdev,Singh ^[3] ; Maya,Azrad ^[4] ; Julia,Bode ^[5] ; Alex,Vainshtein ^[6] ; Beatriz,Caballero ^[7] ; Ilan,Marek ^[8] ; Moshe,Gavish ^[9]

作者单位： The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. nasra19@campus.technion.ac.il. ^[1] The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. veenmanl@tx.technion.ac.il. ^[2] Faculty of Chemistry, Department of Organic Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel. sukhdev.giri@gmail.com. ^[3] The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. mayabz@gmail.com. ^[4] Schaller Research Group at the University of Heidelberg and the German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany. j.bode@dkfz-heidelberg.de. ^[5] The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. alexanderv21184@gmail.com. ^[6] The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. bea1979c@hotmail.com. ^[7] Faculty of Chemistry, Department of Organic Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel. chilanm@tx.technion.ac.il. ^[8] The Ruth and Bruce Rappaport Faculty of Medicine, Department of Neuroscience, Technion-Israel Institute of Technology, Haifa 32525433, Israel. mgavish@tx.technion.ac.il. ^[9]

关键词 2-Cl-MGV-1 PK 11195 TSPO ligand cell nucleus microscopy mitochondria mitochondrial 18 kDa translocator protein (TSPO)modulation of nuclear gene expression retrograde mitochondrial-nuclear signaling pathway